Azido-PEG4-Val-Cit-PAB-MMAE
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[1869126-64-6]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg4-val-cit-pab-mmae.html
Purity
99.43
Solubility
H2O : < 0.1 mg/mL (ultrasonic; adjust pH to 4 with 0.01 M Acetic acid)
Smiles
Molecular Formula
C69H113N13O17
Molecular Weight
1396.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
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