4′-Hydroxywogonin

4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis[1][2][3].

Product Specifications

CAS Number

[57096-02-3]

Product Name Alternative

8-Methoxyapigenin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Bcl-2 Family; Caspase; IKK; Interleukin Related; NF-κB; p38 MAPK; PI3K; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxywogonin.html

Purity

98.22

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=CC=C(O)C=C2)OC3=C(OC)C(O)=CC(O)=C13

Molecular Formula

C16H12O6

Molecular Weight

300.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Fan C, et, al. 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. PLoS One. 2017 Aug 8;12 (8) :e0181191.