Harmine (hydrochloride)

Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

Product Specifications

CAS Number

[343-27-1]

Product Name Alternative

Telepathine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H351

Target

5-HT Receptor; DYRK

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/harmine-hydrochloride.html

Purity

99.98

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3.Cl

Molecular Formula

C13H13ClN2O

Molecular Weight

248.71

Precautions

H302+H312+H332, H351

References & Citations

[1] Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT (2) and 5-HT (1A) ), dopamine (D (2) ) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60 (2) :121-32.|[2]Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8 (1) :2859.|[3] Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16 (11) :1585-92.|[4]Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12 (6) :7985-91.