nor-NOHA
Product Specifications
UNSPSC Description
nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism[1][2].
Target Antigen
Apoptosis; Arginase
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nor-noha.html
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](N)CCNC(NO)=N
Molecular Weight
176.17
References & Citations
[1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.|[2]Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85(1):147-54.Clin Immunol. 2024 Sep 3:110355.|Front Cell Dev Biol. 2021 Dec 23;9:741911.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112885/nor-NOHA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112885/
Clinical Information
Phase 1
CAS Number
189302-40-7
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
