Nor-NOHA

Nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism[1][2].

Product Specifications

CAS Number

[189302-40-7]

Product Name Alternative

Nω-Hydroxy-nor-L-arginine

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Arginase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nor-noha.html

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](N)CCNC(NO)=N

Molecular Formula

C5H12N4O3

Molecular Weight

176.17

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13 (10) :e0205254.|[2]Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85 (1) :147-54.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

Clin Immunol. 2024 Sep 3:110355.|Cell. 2025 Dec 11;188 (25) :7291-7308.e23.|FASEB J. 2025 Sep 30;39 (18) :e71057.|Front Cell Dev Biol. 2021 Dec 23;9:741911.