NVP-CGM097
NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2.
Product Specifications
CAS Number
[1313363-54-0]
Product Name Alternative
CGM097
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NVP-CGM097.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC=C1[C@@H](C2=CC(OC(C)C)=C(OC)C=C2C3)N(C4=CC=C(N(C[C@@H]5CC[C@@H](N6CC(N(C)CC6)=O)CC5)C)C=C4)C3=O
Molecular Formula
C38H47ClN4O4
Molecular Weight
659.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097) : A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58 (16) :6348-58
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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