BTK ligand 10
BTK ligand 10 is the ligand of BTK. BTK ligand 10 can be used to synthesize NX-2127.
Product Specifications
UNSPSC
12352005
Target
Btk; Ligands for Target Protein for PROTAC; Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-ligand-10.html
Smiles
ClC1=C(N=CC(N2CCCCC2)=N1)C(N)=O
Molecular Formula
C10H13ClN4O
Molecular Weight
240.69
References & Citations
[1]Robbins DW, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67 (4) :2321-2336.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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