Flocoumafen

Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects[1][2][3].

Product Specifications

CAS Number

[90035-08-8]

Product Name Alternative

WL 108366

UNSPSC

12352005

Hazard Statement

H300+H310+H330, H360, H372, H410

Target

Glucocorticoid Receptor; MMP; VKOR

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/flocoumafen.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C2CC(C3=CC=C(OCC4=CC=C(C(F)(F)F)C=C4)C=C3)CC5=C2C=CC=C5)=C(O)C6=CC=CC=C6O1

Molecular Formula

C33H25F3O4

Molecular Weight

542.54

Precautions

H300+H310+H330, H360, H372, H410

References & Citations

[1]Nadia Coronado-Posada, et al. In Silico Analysis to Identify Molecular Targets for Chemicals of Concern: The Case Study of Flocoumafen, an Anticoagulant Pesticide. Environ Toxicol Chem. 2021 Jul;40 (7) :2034-2043.|[2]Sébastien Lefebvre, et al. Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences.|[3]Huckle KR, et al. Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration. Xenobiotica. 1988 Dec;18 (12) :1465-79.