GSK2245035 (maleate)
GSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN) -stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma[1].
Product Specifications
CAS Number
1325212-97-2
UNSPSC
12352005
Target
IFNAR; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk2245035-maleate.html
Smiles
OC(/C=C\C(O)=O)=O.O=C(N(C1=NC(O[C@@H](C)CCC)=N2)CCCCCN3CCCCC3)NC1=C2N
Molecular Formula
C24H38N6O6
Molecular Weight
506.60
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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