Calcium channel-modulator-1

Calcium channel-modulator-1 is an orally active calcium channel modulator that blocks aortic contraction with an IC50 of 0.8 μM. Calcium channel-modulator-1 can be used for the study of cardiovascular conditions[1].

Product Specifications

CAS Number

[136941-70-3]

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3,5-Pyridinedicarboxylic_acid,_4-_2,3-dichlorophenyl_-1,4-dihydro-2,6-dimethyl-,_methyl_3-_3-oxo-1,2-benzisothiazol-2_3H_-yl_propyl_ester,_S,S-dioxide.html

Concentration

10mM

Purity

98.77

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(Cl)=C2Cl)OCCCN(C(C3=C4C=CC=C3)=O)S4(=O)=O

Molecular Formula

C26H24Cl2N2O7S

Molecular Weight

579.45

References & Citations

[1]Sunkel CE, et al. Synthesis of 3-[ (2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl) alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 Jun 26;35 (13) :2407-14.