PROTAC PARP1 degrader

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. PROTAC PARP1 degrader induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader consists of E3 ubiquitinase ligand MDM2 ligand (HY-128836), blue part; target protein ligand PAPR1 ligand (HY-171543), pink part; PROTAC linker N3-PEG4-C2-NH2 (HY-128834), black part[1][2].

Product Specifications

CAS Number

[2369022-68-2]

UNSPSC

12352005

Target

PARP; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-parp1-degrader.html

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O

Molecular Formula

C58H63Cl2N11O10

Molecular Weight

1145.09

References & Citations

[1]Zhang J, et al. Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. J Med Chem. 2022 Dec 22;65 (24) :16099-16127.|[2]Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb) . 2019 Jan 2;55 (3) :369-372.