NCGC00188636

NCGC00188636 is a novel covalent pyruvate kinase (PYK) inhibitor. NCGC00188636 blocks nucleotide binding to the active site of pyruvate kinase. NCGC00188636 can be used for the research of the metabolism of many organisms and cell types.

Product Specifications

CAS Number

[1039980-33-0]

UNSPSC

12352005

Target

Pyk2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ncgc00188636.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=CC=C1SC(C2=C3C=CC=C2)=NS3(=O)=O

Molecular Formula

C14H9NO4S2

Molecular Weight

319.36

References & Citations

[1]Hugh P Morgan, et al. A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. Biochem J. 2012 Nov 15;448 (1) :67-72.