MODAG-001
MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3].
Product Specifications
CAS Number
2648041-72-7
UNSPSC
12352005
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/modag-001.html
Purity
98.55
Solubility
DMSO : 25 mg/mL (ultrasonic) |Methanol : 4.9 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)
Smiles
CN(C)C1=CC=C(C2=NNC(C3=CC(Br)=NC=C3)=C2)C=C1
Molecular Formula
C16H15BrN4
Molecular Weight
343.22
References & Citations
[1]Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23 (12) :6371. |[2]Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887. |[3]Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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