NR2E3 agonist 1

NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research[1].

Product Specifications

CAS Number

[911211-69-3]

UNSPSC

12352005

Target

Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nr2e3-agonist-1.html

Purity

99.48

Solubility

10 mM in DMSO

Smiles

O=C(C1CC1)NC2=CC=C(NC(C3=CC=C(NC(C4=CC=CC=C4Cl)=O)C=C3)=N5)C5=C2

Molecular Formula

C24H19ClN4O2

Molecular Weight

430.89

References & Citations

[1]Wolkenberg SE, et al. Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand. Bioorg Med Chem Lett. 2006 Oct 1;16 (19) :5001-4.