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Anti-PAPK Antibody

Rabbit Polyclonal Antibody specific to PAPK (ALS2CR2)

Product Specifications

Product Name Alternative

STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog, ILP-interacting protein homolog, Polyploidy-associated protein kinase, Pseudokinase ALS2CR2

Gene Name

Stradb

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=Stradb">Stradb</a>

UniProt

Q8K4T3

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Reactivity

Mouse

Immunogen

Synthetic peptide corresponding to amino acids 399-418 (SPWSELEFQFPDDKDPVWEF) of mouse PAPK conjugated to KLH at the C-terminus.

Target Antigen

STE20-related kinase adapter protein beta

Target

PAPK

Clonality

Polyclonal

Type

Antibody

Applications

WB

Field of Research

Neuroscience

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}.

Additionnal Information

Immunoblotting: use at 1:250 dilution. A band of approximately 46-47 kDa is detected. <br><br>Positive control: liver tissue lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/28107.pdf

Specificity

This antibody recognizes mouse PAPK. Sequence homology with human PAPK is 60%.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

PAPK (polyploidy-associated protein kinase) is a new member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival. Activation of a death signal transduction pathway may result in the stimulation of the PAPK promoter which leads to increased PAPK expression and provides a negative feedback signal that prevents cell death. Another name for this protein is ALS2CR2 (amyotrophic lateral sclerosis 2 chromosome region candidate 2, isoform A).

CAS Number

9007-83-4

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