Coproporphyrin III (dihydrochloride)

Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6) . Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit[1].

Product Specifications

CAS Number

[68938-73-8]

Product Name Alternative

Zincphyrin (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/coproporphyrin-iii-dihydrochloride.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(CCC(O)=O)C4=C\C5=N/C(C(CCC(O)=O)=C5C)=C\C(N2)=C1C)=N/3.[H]Cl.[H]Cl

Molecular Formula

C36H40Cl2N4O8

Molecular Weight

727.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Wollenberg MS, et al. Propionibacterium-produced coproporphyrin III induces Staphylococcus aureus aggregation and biofilm formation. mBio. 2014 Jul 22;5 (4) :e01286-14.