AG1024
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM) . AG1024 induces apoptosis and has anti-cancer activity[1][2].
Product Specifications
CAS Number
65678-07-1
Product Name Alternative
Tyrphostin AG 1024
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; IGF-1R; Insulin Receptor
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AG1024.html
Purity
99.50
Solubility
DMSO : ≥ 50 mg/mL
Smiles
N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1
Molecular Formula
C14H13BrN2O
Molecular Weight
305.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Párrizas M, et al. Specific inhibition of IGF-1R and IR tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138 (4) :1427-33.|[2]Deutsch E, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. Br J Cancer. 2004 Nov 1;91 (9) :1735-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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