AG1024

AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM) . AG1024 induces apoptosis and has anti-cancer activity[1][2].

Product Specifications

CAS Number

[65678-07-1]

Product Name Alternative

Tyrphostin AG 1024

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; IGF-1R; Insulin Receptor

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AG1024.html

Purity

99.50

Solubility

DMSO : ≥ 50 mg/mL

Smiles

N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1

Molecular Formula

C14H13BrN2O

Molecular Weight

305.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Párrizas M, et al. Specific inhibition of IGF-1R and IR tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138 (4) :1427-33.|[2]Deutsch E, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. Br J Cancer. 2004 Nov 1;91 (9) :1735-41.