R1530
R1530 is a highly potent, orally active, dual-acting mitosis/angiogenesis inhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases with Kd values of IC50 of 10 nM and 28 nM, respectively. R1530 triggers apoptosis (mitotic catastrophe) or senescence[1][2].
Product Specifications
CAS Number
882531-87-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; FGFR; Mitosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/R1530.html
Concentration
10mM
Purity
99.06
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(NN1)=C2C1=NC3=CC(OC)=C(F)C=C3C(C4=CC=CC=C4Cl)=N2
Molecular Formula
C18H14ClFN4O
Molecular Weight
356.78
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Available Sizes
Frequently Asked Questions
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