Tephrosin
Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1].
Product Specifications
CAS Number
76-80-2
Product Name Alternative
Deguelinol I; Hydroxydeguelin
UNSPSC
12352005
Hazard Statement
H410
Target
EGFR
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tephrosin.html
Purity
98.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1[C@]2(O)[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14
Molecular Formula
C23H22O7
Molecular Weight
410.42
Precautions
H410
References & Citations
[1]Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293 (1) :23-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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