BDE 47

BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish[1].

Product Specifications

CAS Number

[5436-43-1]

UNSPSC

12352005

Hazard Statement

H351, H360, H373, H410

Target

Apoptosis; JNK; Oxidative Phosphorylation; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bde-47.html

Purity

98.37

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

BrC1=CC=C(C(Br)=C1)OC2=CC=C(C=C2Br)Br

Molecular Formula

C12H6Br4O

Molecular Weight

485.79

Precautions

H351, H360, H373, H410

References & Citations

[1]Zhuang J, et al., BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 2020 Nov;258:127385.