BDE 47
BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish[1].
Product Specifications
CAS Number
[5436-43-1]
UNSPSC
12352005
Hazard Statement
H351, H360, H373, H410
Target
Apoptosis; JNK; Oxidative Phosphorylation; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bde-47.html
Purity
98.37
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(C(Br)=C1)OC2=CC=C(C=C2Br)Br
Molecular Formula
C12H6Br4O
Molecular Weight
485.79
Precautions
H351, H360, H373, H410
References & Citations
[1]Zhuang J, et al., BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 2020 Nov;258:127385.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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