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BDE 47

Product Specifications

UNSPSC Description

BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish[1].

Target Antigen

Apoptosis; JNK; Oxidative Phosphorylation; Reactive Oxygen Species

Type

Reference compound

Related Pathways

Apoptosis;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bde-47.html

Purity

98.37

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

BrC1=CC=C(C(Br)=C1)OC2=CC=C(C=C2Br)Br

Molecular Weight

485.79

References & Citations

[1]Zhuang J, et al., BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 2020 Nov;258:127385.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W762011/BDE-47-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W762011/BDE-47-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

5436-43-1

Available Sizes

Curated Selection

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