Torkinib
Product Specifications
UNSPSC Description
Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM[1]. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively[2].
Target Antigen
Apoptosis; Autophagy; Mitophagy; mTOR
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PP-242.html
Purity
98.29
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=C2C(N(N=C2C3=CC4=C(N3)C=CC(O)=C4)C(C)C)=NC=N1
Molecular Weight
308.34
References & Citations
[1]Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.|[2]Feldman ME, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10;7(2):e38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10474/Torkinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10474/Torkinib-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1092351-67-1
Available Sizes
Curated Selection
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