Terodiline
Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence[1][2].
Product Specifications
CAS Number
15793-40-5
UNSPSC
12352005
Target
Calcium Channel; mAChR; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/terodiline.html
Solubility
10 mM in DMSO
Smiles
CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2
Molecular Formula
C20H27N
Molecular Weight
281.44
References & Citations
[1]Ruth L Martin, et al. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol. 2006 Nov;48 (5) :199-206.|[2]H D Langtry, et al. Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence. Drugs. 1990 Nov;40 (5) :748-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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