Dextran sulfate sodium salt (MW 450000-550000)

Dextran sulfate sodium salt (DSS) (MW 450000-550000) is a polymer of dehydrated glucose with a molecular weight of approximately 450000-550000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 450000-550000) inhibits replication of HIV-1 and influenza A virus. Dextran sulfate sodium salt (MW 450000-550000) can be formulated as nanoparticles and shows antibacterial activity. Dextran sulfate sodium salt (MW 450000-550000) can be used for functional material preparation[1][2][3][4][5][6].

Product Specifications

CAS Number

[9011-18-1]

Product Name Alternative

DSS (MW 450000-550000) ; DXS (MW 450000-550000)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neurodegeneration

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dextran-sulfate-sodium-salt-mw-500000.html

Purity

95.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Dextransulfatesodiumsalt(MW450000-550000)]

Molecular Weight

450000-550000

Precautions

H302, H315, H319, H335

References & Citations

[1]Madkhali OA, et al. E. Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent. Sci Rep. 2021 May 10;11 (1) :9914. |[2]Aaltonen N, et al. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils. Biol Proced Online. 2020 Mar 15;22:6. |[3]Tiyaboonchai W, et al. Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles. Eur J Pharm Sci. 2003 Jul;19 (4) :191-202. |[4]Erdtmann M, et al. Photochemical immobilization of heparin, dermatan sulphate, dextran sulphate and endothelial cell surface heparan sulphate onto cellulose membranes for the preparation of athrombogenic and antithrombogenic polymers. Biomaterials. 1994 Oct;15 (13) :1043-8. |[5]Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85 (16) :6132-6. |[6]Lüscher-Mattli M, et al. Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo. Antiviral Res. 1990 Jul;14 (1) :39-50.