Pomalidomide-C2-amide-C4-Br
Pomalidomide-C2-amide-C4-Br is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-C2-amide-C4-Br can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[2545963-02-6]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-c2-amide-c4-br.html
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCNC(CCCCBr)=O)=CC=C3)=O)=O
Molecular Formula
C20H23BrN4O5
Molecular Weight
479.32
References & Citations
[1]Chengchun Zhu, et al. Design, Synthesis and Antitumor Activity of a Novel Class of SHP2 Allosteric Inhibitors with a Furanyl Amide-Based Scaffold. J Med Chem. 2024 Aug 8;67 (15) :13305-13323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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