Metformin-d6 (hydrochloride)
Metformin-d6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo[1].
Product Specifications
CAS Number
[1185166-01-1]
Product Name Alternative
1,1-Dimethylbiguanide-d6 (hydrochloride)
UNSPSC
12352211
Hazard Statement
H302, H315, H319
Target
AMPK; Apoptosis; Autophagy; Isotope-Labeled Compounds; Mitophagy; mTOR
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Epigenetics; Others; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Cardiovascular Disease
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
NC(NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)=N.[H]Cl
Molecular Formula
C4H6D6ClN5
Molecular Weight
171.66
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
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