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ATSP-7041

ATSP-7041, a selective dual peptide inhibitor of MDM2 and MDMX, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers[1].

Product Specifications

CAS Number

1451197-99-1

UNSPSC

12352209

Target

MDM-2/p53

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atsp-7041.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC([C@@H](NC([C@@](C)(CCCCCC/C=C/CCC[C@](C)(NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)C)=O)CCC(N)=O)=O)CC2CCC2)=O)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N)=O)=O)=O)=O)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)=O)CCC(O)=O)=O)CC4=CC=C(C=C4)O)N[C@H]1CC5=CNC6=CC=CC=C56

Molecular Formula

C87H125N17O21

Molecular Weight

1745.02

References & Citations

[1]Yong S Chang, et al. Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc Natl Acad Sci U S A. 2013 Sep 3;110 (36) :E3445-54.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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