ATSP-7041
ATSP-7041, a selective dual peptide inhibitor of MDM2 and MDMX, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers[1].
Product Specifications
CAS Number
1451197-99-1
UNSPSC
12352209
Target
MDM-2/p53
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atsp-7041.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@@H](NC([C@@](C)(CCCCCC/C=C/CCC[C@](C)(NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)C)=O)CCC(N)=O)=O)CC2CCC2)=O)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N)=O)=O)=O)=O)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)=O)CCC(O)=O)=O)CC4=CC=C(C=C4)O)N[C@H]1CC5=CNC6=CC=CC=C56
Molecular Formula
C87H125N17O21
Molecular Weight
1745.02
References & Citations
[1]Yong S Chang, et al. Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc Natl Acad Sci U S A. 2013 Sep 3;110 (36) :E3445-54.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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