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TCO-PEG3-amine

TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG3-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

CAS Number

1800507-93-0

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg3-amine.html

Purity

96.49

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCN

Molecular Formula

C17H32N2O5

Molecular Weight

344.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10 (2) :207-238.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Frequently Asked Questions

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