BRPF1B/TRIM24-IN-1

BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].

Product Specifications

CAS Number

[1242907-48-7]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brpf1b-trim24-in-1.html

Smiles

O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC=C(OC)C=C3)C=C(N4C)C(N(C)C4=O)=C2)=O

Molecular Formula

C24H25N3O7S

Molecular Weight

499.54

References & Citations

[1]Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59 (4) :1642-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRPF1; BRPF2

Curated Selection

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