BRPF1B/TRIM24-IN-1
Product Specifications
UNSPSC Description
BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brpf1b-trim24-in-1.html
Smiles
O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC=C(OC)C=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
Molecular Weight
499.54
References & Citations
[1]Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122626/BRPF1B-TRIM24-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122626/
Clinical Information
No Development Reported
CAS Number
1242907-48-7
Curated Selection
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