RPS6-IN-1
RPS6-IN-1 (Compound 22o) inhibits cell metastasis, induces cell apoptosis (increases the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP) . RPS6-IN-1 decreases mitochondrial membrane potential. RPS6-IN-1 activates autophagy through the PI3K-Akt-mTOR signaling pathway, damages intracellular mitochondria and lysosomes, and cause ER stress. RPS6-IN-1 inhibits RPS6 phosphorylation. RPS6-IN-1 is an anticancer agent with low systemic toxicity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; Bcl-2 Family; Caspase; MDM-2/p53; PARP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-247.html
Smiles
ClC1=NC(Cl)=NC2=C1N=CN2C3(C(OCC)=O)CSC[C@H]3CC(OCC)=O
Molecular Formula
C16H18Cl2N4O4S
Molecular Weight
433.31
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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