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Anti-TRAP1/Hsp75 Antibody

Mouse Monoclonal Antibody specific to Trap1

Product Specifications

Product Name Alternative

HSP 75, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1

Gene Name

TRAP1

Gene ID

10131

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TRAP1">TRAP1</a>

UniProt

Q12931

Accession Number

NP_057376.2

Cellular Locus

Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix

Host

Mouse

Reactivity

Human, Rat

Immunogen

Recombinant human TRAP1

Target Antigen

Heat shock protein 75 kDa, mitochondrial

Target

TRAP1/Hsp75

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB

Field of Research

Heat Shock& Stress Proteins

Purification Method

Purified by Protein G affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {PubMed:23525905, PubMed:23564345, PubMed:23747254}.

Additionnal Information

Immunoblotting: use at 1ug/mL. A band of ~75kDa is detected. <br><br>Positive control: A431 cell lysate or rat brain lysate. <br><br>These are recommended concentrations; <br><br>Enduser should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/11143.pdf

Specificity

This antibody recognizes human and rat TRAP1. Other species have not been investigated.

Formulation

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.Purified by Protein G affinity chromatography.

Buffer pH

pH 7.4

Target Background

The molecular chaperone family of 90kDa heat shock proteins (Hsp90) is a highly conserved protein family that plays an important physiological role. Hsp90 is best known for its association with signal transduction processes. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a recently cloned homolog of Hsp90. Like Hsp90, TRAP1 is associated with numerous proteins that are involved in multiple pathways. Data indicates that TRAP1 is a mitochondrial matrix protein: it is localized in mitochondria of mammalian cells and contains a mitochondrial targeting presequence.

CAS Number

9007-83-4

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