(S) -Baclofen

(S) -Baclofen is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC50 values of 1.77 μM for GABAB and 1564 μM for GABAA. (S) -Baclofen can be used in research on muscle disorders such as spasticity[1][2].

Product Specifications

CAS Number

[66514-99-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-baclofen.html

Solubility

10 mM in DMSO

Smiles

O=C(C[C@@H](C1=CC=C(C=C1)Cl)CN)O

Molecular Formula

C10H12ClNO2

Molecular Weight

213.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Froestl W, et al. Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995;38 (17) :3297-3312.|[2]He Q, et al. Simultaneous Quantitation of S (+) - and R (-) -Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules. 2020 Jan 8;25 (2) :250.