4'-Demethylepipodophyllotoxin

4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

Product Specifications

CAS Number

[6559-91-7]

Product Name Alternative

4'-O-demethylepipodophyllotoxin; 4'-DMEP

UNSPSC

12352005

Hazard Statement

H350, H360

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4_acute_-demethylepipodophyllotoxin.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H]

Molecular Formula

C21H20O8

Molecular Weight

400.38

Precautions

H350, H360

References & Citations

[1]Tang YJ, Zhao W, Li HM. Novel tandem biotransformation process for the biosynthesis of a novel compound, 4- (2,3,5,6-tetramethylpyrazine-1) -4'-demethylepipodophyllotoxin. Appl Environ Microbiol. 2011 May;77 (9) :3023-34.|[2]Dhawan D, Balasubramanian S, Amonkar AJ, Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis. Carcinogenesis. 1999 Jun;20 (6) :997-1003.|[3]Xiang Zhou, et al. The discovery of natural 4'-demethylepipodophyllotoxin from renewable Dysosma versipellis species as a novel bacterial cell division inhibitor for controlling intractable diseases in rice. Industrial Crops and Products. Volume 174, 15 December 2021, 114182