C-8 Ceramide-1-phosphate

C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis[1][2].

Product Specifications

CAS Number

[158983-53-0]

UNSPSC

12352211

Target

Apoptosis; DNA/RNA Synthesis; PI3K

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/c-8-ceramide-1-phosphate.html

Purity

99.0

Smiles

CCCCCCCC(N[C@@H](COP(O)(O)=O)[C@H](O)/C=C/CCCCCCCCCCCCC)=O

Molecular Formula

C26H52NO6P

Molecular Weight

505.67

References & Citations

[1]Gomez-Muñoz A, et al. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol. 1995 May;47 (5) :833-9. PMID: 7746276.|[2]Gómez-Muñoz A. Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim Biophys Acta. 2006 Dec;1758 (12) :2049-56.