Glabrene

Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 of 3.5 μM[1][2].

Product Specifications

CAS Number

60008-03-9

UNSPSC

12352005

Target

Tyrosinase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glabrene.html

Solubility

10 mM in DMSO

Smiles

OC1=C2C=CC(C)(C)OC2=C(C3=CC4=CC=C(O)C=C4OC3)C=C1

Molecular Formula

C20H18O4

Molecular Weight

322.35

References & Citations

[1]Somjen D, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. 2004 Aug;91 (4-5) :241-6.|[2]Nerya O, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51 (5) :1201-7