(R) -ML375
(R) -ML375 ((R) -VU0483253) is an enantiomer of ML375. (R) -ML375 is devoid of M5 mAChR activity (hM5, IC50>30 μM).
Product Specifications
CAS Number
1488362-56-6
Product Name Alternative
(R) -VU0483253
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Isomer
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/r-ml375.html
Purity
98.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N2[C@](N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C=C4)C5=C1C=CC=C5
Molecular Formula
C23H15ClF2N2O2
Molecular Weight
424.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Patrick R Gentry, et al. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S) -9b- (4-chlorophenyl) -1- (3,4-difluorobenzoyl) -2,3-dihydro-1H-imidazo[2,1-a]isoindol-5 (9bH) -one (ML375) . J Med Chem. 2013 Nov 27;56 (22) :9351-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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