Human CTGF Protein

<strong>Human CTGF Protein</strong>_x000D_ <strong>Catalog number:</strong> B2012066_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> Connective tissue growth factor protein, CCN2 protein, NOV2 protein, HCS24 protein, IGFBP8 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, Yamada R, Hikita H, Sakamori R, Akita H, Eguchi H, Johnson RL, Yokoi H, Mukoyama M, Tatsumi T, Takehara T. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation J Clin Invest. 2021 Jul 1;131(13):e143414._x000D_ 2: Muromachi K, Kamio N, Matsumoto T, Matsushima K. Role of CTGF/CCN2 in reparative dentinogenesis in human dental pulp J Oral Sci. 2012 Mar;54(1):47-54._x000D_ 3: Chen HY, Lin CH, Chen BC. ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts Exp Cell Res. 2018 Sep 1;370(1):39-45._x000D_ 4: Tsai HC, Huang CY, Su HL, Tang CH. CTGF increases drug resistance to paclitaxel by upregulating survivin expression in human osteosarcoma cells Biochim Biophys Acta. 2014 May;1843(5):846-54._x000D_ 5: Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y. COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis J Dermatol Sci. 2019 Apr;94(1):205-212._x000D_ 6: Shieh JM, Tsai YJ, Chi JC, Wu WB. TGFβ mediates collagen production in human CRSsNP nasal mucosa-derived fibroblasts through Smad2/3-dependent pathway and CTGF induction and secretion J Cell Physiol. 2019 Jul;234(7):10489-10499._x000D_ 7: Laug R, Fehrholz M, Schütze N, Kramer BW, Krump-Konvalinkova V, Speer CP, Kunzmann S. IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells PLoS One. 2012;7(9):e45430._x000D_ 8: Lu C, Liu Z, Zhang H, Duan Y, Cao Y. [Mechanism of p38 mitogen activated protein kinase signaling pathway on promoting the hypertrophy of human lumbar ligamentum flavum via transforming growth factor β (1)/connective tissue growth factor] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2019 Jun 15;33(6):730-735._x000D_ 9: Liu SC, Hsu CJ, Chen HT, Tsou HK, Chuang SM, Tang CH. CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway PLoS One. 2012;7(12):e51097._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/18287089">10: Black SA Jr, Trackman PC. Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression J Biol Chem. 2008 Apr 18;283(16):10835-47. </a>_x000D_ _x000D_ <strong>Products Related to Human CTGF Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>