2- (2- (2- (6-Azidohexanamido) ethoxy) ethoxy) acetic acid
2- (2- (2- (6-Azidohexanamido) ethoxy) ethoxy) acetic acid is a PROTACT linker and can be used for synthesis of P60-L3-VHL (HY-162943) . 2- (2- (2- (6-Azidohexanamido) ethoxy) ethoxy) acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups[1].
Product Specifications
CAS Number
[3036674-82-2]
UNSPSC
12352211
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-2-2-6-azidohexanamido-ethoxy-ethoxy-acetic-acid.html
Smiles
O=C(O)COCCOCCNC(CCCCCN=[N+]=[N-])=O
Molecular Formula
C12H22N4O5
Molecular Weight
302.33
References & Citations
[1]Yang B, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3. Bioorg Med Chem Lett. 2024 Nov 1;112:129945.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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