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2- (2- (2- (6-Azidohexanamido) ethoxy) ethoxy) acetic acid

2- (2- (2- (6-Azidohexanamido) ethoxy) ethoxy) acetic acid is a PROTACT linker and can be used for synthesis of P60-L3-VHL (HY-162943) . 2- (2- (2- (6-Azidohexanamido) ethoxy) ethoxy) acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups[1].

Product Specifications

CAS Number

[3036674-82-2]

UNSPSC

12352211

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-2-2-6-azidohexanamido-ethoxy-ethoxy-acetic-acid.html

Smiles

O=C(O)COCCOCCNC(CCCCCN=[N+]=[N-])=O

Molecular Formula

C12H22N4O5

Molecular Weight

302.33

References & Citations

[1]Yang B, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3. Bioorg Med Chem Lett. 2024 Nov 1;112:129945.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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