Fas Ligand, Mouse (P.pastoris, His)

Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development[1]. Mouse Fas Ligand has a total length of 279 amino acids (M1-L279), with a TNF_2 domain (144-279 a.a.) . Fas Ligand Protein, Mouse (P.pastoris, His) is a recombinant protein expressed in P.pastoris cells with N-terminal His-tag.

Product Specifications

Product Name Alternative

Fas Ligand Protein, Mouse (P.pastoris, His), Mouse, P. pastoris

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/fas-ligand-protein-mouse-p-pastoris-his.html

Purity

94.40

Molecular Formula

14103 (Gene_ID) Q544E9 (P132-L279) (Accession)

Molecular Weight

Approximately 18.2 kDa

References & Citations

[1]Schneider P, et al. Characterization of Fas (Apo-1, CD95) -Fas ligand interaction. J Biol Chem. 1997 Jul 25;272 (30) :18827-33.|[2]Liu W, et al. Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure. 2016 Nov 1;24 (11) :2016-2023.|[3]Martínez-Lorenzo MJ, et al. Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology. 1996 Dec;89 (4) :511-7.|[4]Puppo F, et al. Fas, Fas ligand, and transfusion immunomodulation. Transfusion. 2001 Mar;41 (3) :416-8.|[5]Miwa K, et al. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med. 1998 Nov;4 (11) :1287-92.|[6]Shudo K, et al. The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity. Eur J Immunol. 2001 Aug;31 (8) :2504-11.