Cyclo (RGDyK)

Cyclo (RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Product Specifications

CAS Number

[217099-14-4]

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclo-rgdyk.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@@H](N2)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(O)=O)C2=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O

Molecular Formula

C27H41N9O8

Molecular Weight

619.67

References & Citations

[1]Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42 (2) :326-36.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

αvβ3

Citation 01

Biochem Pharmacol. 2023 Nov:217:115808.|J Adv Res. 2025 May 25:S2090-1232 (25) 00370-4.|Pharmaceuticals (Basel) . 2021 Mar 14;14 (3) :260.|Stem Cell Res Ther. 2022 Jul 18;13 (1) :327.