DCH36_06
DCH36_06 is a potent and selective p300/CBP inhibitor with IC50s of 0.6 μM and 3.2 μM for p300 and CBP, respectively. DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. Anti-tumor activity[1].
Product Specifications
CAS Number
593273-05-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dch36-06.html
Purity
99.19
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(/C(C(N1C2=CC=C(C)C(Cl)=C2)=O)=C\C=C\C3=CC=CO3)NC1=S
Molecular Formula
C18H13ClN2O3S
Molecular Weight
372.83
Precautions
H302, H315, H319
References & Citations
[1]Wenchao Lu, et al. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors. Bioorg Med Chem. 2018 Nov 1;26 (20) :5397-5407.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Available Sizes
Frequently Asked Questions
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