DCH36_06

DCH36_06 is a potent and selective p300/CBP inhibitor with IC50s of 0.6 μM and 3.2 μM for p300 and CBP, respectively. DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. Anti-tumor activity[1].

Product Specifications

CAS Number

[593273-05-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dch36-06.html

Purity

99.19

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(/C(C(N1C2=CC=C(C)C(Cl)=C2)=O)=C\C=C\C3=CC=CO3)NC1=S

Molecular Formula

C18H13ClN2O3S

Molecular Weight

372.83

Precautions

H302, H315, H319

References & Citations

[1]Wenchao Lu, et al. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors. Bioorg Med Chem. 2018 Nov 1;26 (20) :5397-5407.