Human BPHL Protein

<strong>Human BPHL Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011646_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> VACVASE, Valacyclovir hydrolase protein, BPH-RP protein, MCNAA protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase PLoS One. 2014 Oct 15;9(10):e110054._x000D_ 2: Kim I, Chu XY, Kim S, Provoda CJ, Lee KD, Amidon GL. Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase J Biol Chem. 2003 Jul 11;278(28):25348-56._x000D_ 3: Puente XS, Pendás AM, López-otín C. Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL) Genomics. 1998 Aug 1;51(3):459-62._x000D_ 4: Kim I, Crippen GM, Amidon GL. Structure and specificity of a human valacyclovir activating enzyme: a homology model of BPHL Mol Pharm. 2004 Nov-Dec;1(6):434-46._x000D_ 5: Shenoy VM, Thompson BR, Shi J, Zhu HJ, Smith DE, Amidon GL. Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme Mol Pharm. 2020 May 4;17(5):1706-1714._x000D_ 6: Tao W, Zhao D, Sun M, Li M, Zhang X, He Z, Sun Y, Sun J. Enzymatic activation of double-targeted 5'-O-L-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis Drug Deliv Transl Res. 2017 Apr;7(2):304-311._x000D_ 7: Chu C, Liu BZ, Zhong L, Wu XJ, Zhu D, Wu Y. [Identification of interaction between BPHL and PML-C] Chu C, Liu BZ, Zhong L, Wu XJ, Zhu D, Wu Y._x000D_ 8: Kim I, Song X, Vig BS, Mittal S, Shin HC, Lorenzi PJ, Amidon GL. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein Mol Pharm. 2004 Mar-Apr;1(2):117-27._x000D_ 9: Hu Y, Epling D, Shi J, Song F, Tsume Y, Zhu HJ, Amidon GL, Smith DE. Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice Biochem Pharmacol. 2018 Oct;156:147-156._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/16316342">10: Melk A, Mansfield ES, Hsieh SC, Hernandez-Boussard T, Grimm P, Rayner DC, Halloran PF, Sarwal MM. Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling Kidney Int. 2005 Dec;68(6):2667-79. </a>_x000D_ _x000D_ <strong>Products Related to Human BPHL Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>