Hsp90-IN-34
Hsp90-IN-34 (compound HAM-1) is a compound that inhibits the Aha1-Hsp90 chaperone complex with a high affinity for Hsp90/Aha1 (KDapp=23.5 µM) . Hsp90-IN-34 modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1[1].
Product Specifications
CAS Number
439588-33-7
UNSPSC
12352101
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-in-34.html
Smiles
N#CC1=C(N)OC2=C(C1C3=CNN=C3C4=CC=C(F)C=C4)C(C5=CC=C(F)C=C5)=NN2
Molecular Formula
C22H14F2N6O
Molecular Weight
416.38
References & Citations
[1]Stiegler S C, et al. A chemical compound inhibiting the Aha1–Hsp90 chaperone complex[J]. Journal of Biological Chemistry, 2017, 292 (41) : 17073-17083.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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