Reversin 121
Product Specifications
UNSPSC Description
Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers[1][2].
Target Antigen
P-glycoprotein
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/reversin-121.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCC[C@@H](C(OC(C)(C)C)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC(OCC1=CC=CC=C1)=O)=O)OCC2=CC=CC=C2
Molecular Weight
641.75
References & Citations
[1]Hoffmann K, et al. Effects of the high-affinity Peptide reversin 121 on multidrug resistance proteins in experimental pancreatic cancer. Tumour Biol. 2008;29(6):351-8. |[2]Yabuki N, et al. Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance. Cancer Genet Cytogenet. 2007 Feb;173(1):1-9. |[3]Kooij G, et al. P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS One. 2009 Dec 8;4(12):e8212.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125486/Reversin-121-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125486/Reversin-121-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
174630-04-7
Available Sizes
Curated Selection
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