Reversin 121

Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers[1][2].

Product Specifications

CAS Number

[174630-04-7]

UNSPSC

12352209

Target

P-glycoprotein

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/reversin-121.html

Purity

99.08

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCCC[C@@H](C(OC(C)(C)C)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC(OCC1=CC=CC=C1)=O)=O)OCC2=CC=CC=C2

Molecular Formula

C34H47N3O9

Molecular Weight

641.75

References & Citations

[1]Hoffmann K, et al. Effects of the high-affinity Peptide reversin 121 on multidrug resistance proteins in experimental pancreatic cancer. Tumour Biol. 2008;29 (6) :351-8. |[2]Yabuki N, et al. Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance. Cancer Genet Cytogenet. 2007 Feb;173 (1) :1-9. |[3]Kooij G, et al. P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS One. 2009 Dec 8;4 (12) :e8212.