(R) -JNJ-40418677
(R) -JNJ-40418677 is the R-enantiomer of JNJ-40418677.
Product Specifications
CAS Number
1146594-85-5
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/r-jnj-40418677.html
Purity
99.6700
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)C[C@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=CC(C3=CC=C(C=C3)C(F)(F)F)=C1)C(O)=O
Molecular Formula
C26H22F6O2
Molecular Weight
480.44
References & Citations
[1]Van Broeck B, et al. Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011 May;163 (2) :375-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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