DACA
DACA (XR 5000) is a blood-brain barrier-penetrating topoisomerase I and II inhibitor. DACA can be used in the research of colorectal cancer, leukemia and lung cancer[1][2][3][4].
Product Specifications
CAS Number
89459-25-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/daca.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CC2=CC3=CC=CC=C3N=C12)NCCN(C)C
Molecular Formula
C18H19N3O
Molecular Weight
293.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Padget K, et al. An investigation into the formation of N- [2- (dimethylamino) ethyl]acridine-4-carboxamide (DACA) and 6-[2- (dimethylamino) ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000;60 (6) :817-821.|[2]Dittrich C, et al. Phase II study of XR 5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with non-small cell lung cancer. Eur J Cancer. 2003 Feb;39 (3) :330-4. |[3]Caponigro F, et al. Phase II study of XR 5000, an inhibitor of topoisomerases I and II, in advanced colorectal cancer. Eur J Cancer. 2002 Jan;38 (1) :70-4. |[4]Twelves CJ, et al. Phase I and pharmacokinetic study of DACA (XR5000) : a novel inhibitor of topoisomerase I and II. CRC Phase I/II Committee. Br J Cancer. 1999 Aug;80 (11) :1786-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I; Topo II
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1332115-01 0.02 mg (E-Coli)
Recombinant Brucella abortus biovar 1 sn-glycerol-3-phosphate-binding periplasmic protein ugpB (ugpB)
Sign In for Pricing
View Details MBS1332115-02 0.02 mg (Yeast)
Recombinant Brucella abortus biovar 1 sn-glycerol-3-phosphate-binding periplasmic protein ugpB (ugpB)
Sign In for Pricing
View Details MBS1332115-03 0.1 mg (E-Coli)
Recombinant Brucella abortus biovar 1 sn-glycerol-3-phosphate-binding periplasmic protein ugpB (ugpB)
Sign In for Pricing
View Details MBS1332115-04 0.1 mg (Yeast)
Recombinant Brucella abortus biovar 1 sn-glycerol-3-phosphate-binding periplasmic protein ugpB (ugpB)
Sign In for Pricing
View Details MBS1332115-05 0.02 mg (Baculovirus)
Recombinant Brucella abortus biovar 1 sn-glycerol-3-phosphate-binding periplasmic protein ugpB (ugpB)
Sign In for Pricing
View Details