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CGS 15943

CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. [1][2].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor; PI3K

Type

Reference compound

Related Pathways

GPCR/G Protein; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cgs-15943.html

Purity

99.55

Solubility

DMSO : 12.22 mg/mL (ultrasonic)

Smiles

NC1=NC2=C(C=C(Cl)C=C2)C3=NC(C4=CC=CO4)=NN13

Molecular Formula

C13H8ClN5O

Molecular Weight

285.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55 (3) :PL61-5.|[2]Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362 (4-5) :382-91.|[3]Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15 (5) :524-32.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100678/CGS-15943-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100678/CGS-15943-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3Kγ; PI3Kδ

CAS Number

[104615-18-1]

Available Sizes

Curated Selection

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